The following discussion is educational and is not medical advice. It does not imply a physician-patient relationship, nor is anything discussed herein intended to advocate for any specific medical treatment or therapy, or to replace standard accepted medical care by a trained healthcare professional. If you are injured or ill, seek immediate and definitive care from a licensed professional.
Preventative care is the first line of defense against injury and illness. In general populations, this typically consists of things like routine physical exams and bloodwork, immunizations, and lifestyle advice. Many of the general guidelines regarding preventative care are, expectedly, general. They’re often derived from averages and, of course, many populations exist in either direction of the median.
It’s difficult to convince the average person to undergo a rigorous, structured program of physical development; so, this potent prophylaxis is often unprescribed.[3,4]
Training implies a developmental process, conducted in accordance with an intended outcome; activity implies movement, but perhaps without a specific structure or destination in mind. For the sake of this article, let’s consider the role of physical training in preventative care, as opposed to general physical activity, and its latent potential for developing strong, vital, and resilient human beings.
When utilizing physical training as a tool for preventative care, it’s critical to understand how the “prescription” works. For this, I point to the model of General Adaptation Syndrome[1], as well as the principle of Specific Adaptation to Imposed Demands[2].
A Grail Strength guest dispatch. Medically reviewed by Matthew J. Bertini, MD.
General Adaptation Syndrome: How the Body Adapts to Training Stress
General Adaptation Syndrome, as introduced by endocrinologist Hans Selye, details an organism’s potential responses to stress: alarm, resistance, and exhaustion. While initially intended as a framework for responsiveness to any stress, (including life-or-death situations,) it is immensely useful when applied to the context of physical training; let’s examine it as such.
What is General Adaptation Syndrome? Simply, it’s the body’s conditional response to any stressful stimulus: alarm (the immediate effect), resistance (durability or immunity developed by repeated exposure to stress), and exhaustion (the consequential deterioration, when stress is unable to be resisted or accommodated).
When an unaccustomed, stressful stimulus is applied to an organism (like lifting a heavy weight,) the organism often exhibits a state of alarm — heightened sympathetic nervous system activity, inflammation of tissues, and elevation of stress hormones are expected responses to difficult physical training. If the applied stressful stimulus is tolerated, the organism may develop a resistance to it; greater magnitudes of stress (or heavier weights) will be needed to disrupt equilibrium, in the future. If the stressful stimulus is not able to be accommodated, the organism may display a condition of exhaustion; this includes injury, fatigue, functional overreaching, or overtraining. Sound physical training is a constant Goldilocks problem: seeking that ever-changing “just right,” in terms of application of novel stimulus, to drive adaptation, while avoiding exhaustion or overwhelm. In this regard, it is important to consider what the “minimum effective dose” may be, in any given context.[5] Prescription of physical training, both from a qualitative and quantitative perspective, benefits from precision; the dose must match the indication.
Beyond General Adaptation Syndrome, there is the principle of Specific Adaptation to Imposed Demands. In essence, this principle conveys the following: we adapt to what we repeatedly do. If the cardiovascular system, for example, is not stressed in a specific, intentional manner (i.e. development of aerobic capacity below the first lactate threshold,) it is unreasonable to believe that specific, intentional adaptations will occur.
When utilizing physical training as a preventative care method, consider the following: it should be potent enough to drive an adaptation, specific enough to develop an intended adaptation, and measured enough to not plunge the patient into a state of exhaustion.
So, practically, what does this look like?
For ease of application, I often divide exercise-induced adaptations into three categories: structural, chemical, and neural. Of course, the body contains near-infinite degrees of complex sub-systems, but distilling outcomes of training into a threefold framework allows for streamlined navigation. With this in mind, let’s consider some of the highest “return-on-investment” training objectives, as well as how these adaptations benefit clinical outcomes, quality of life, and physical performance.
Structural: Development of Musculoskeletal Tissues
The musculoskeletal system consists of, predictably: muscles, bones, and everything that connects them. For the purpose of preventative care — building strong, resilient, durable patients — we’ll consider the structural components of this system. (Of course, chemical [or metabolic] and neural adaptations strongly influence musculoskeletal function, as well.) Bottom line up front: the musculoskeletal system benefits from progressive exposure to relatively high forces, safely, over time.[6,7] At a structural level, bones, tendons, and muscles are stress adaptive; ligaments are also stress adaptive, but to a much lesser degree. By utilizing progressive resistance training, muscle cross-sectional area may increase, bone mineral density may increase, tissues may display greater resistance to externally-applied forces (minimized risk for certain acute injuries, like sprained ankles,) and the entire platform upon which the human organism sits may grow stronger.[8,9,10] Progressive resistance training is a tremendously potent, widely underutilized preventative care method for the body’s locomotive components — not to mention its tremendous benefits for metabolic health.[11,12,13]
When considering the most efficient tool for musculoskeletal development, barbells are often the most effective choice; this is conditionally dependent on the individual’s ability to precisely and safely execute barbell lifts. Provided that this is the case, barbells provide a consistent platform to progressively, heavily load the human body in such a way that few implements can parallel. The combination of progressive barbell strength work and deliberate metabolic conditioning (often lumped into the ubiquitous “hybrid athlete training” umbrella, although it’s really just concurrent training,) is a potent method for whole-system development.[11,14] For a more granular look at this, I recommend reading “Quantum Strength and Power Training: Gaining the Winning Edge,” by Dr. Pat O’Shea — if you can find a copy of it.[15]
Chemical: Development of Aerobic Metabolism
Aerobic exercise is one of the most prevalent prescriptions of preventative care. The American Heart Association recommends at least 150 minutes of moderate-intensity aerobic activity, or 75 minutes of vigorous aerobic activity, per week.[16,17] Everyone knows that aerobic activity is good for you — but, what is aerobic activity? Aerobic metabolism, in the context of exercise, is vastly misunderstood. Much of what we refer to as “aerobic” activity is, in actuality, some combination of aerobic and anaerobic activity; unfortunately, this often applies to the storied “Zone 2” heart rate. Allow me to explain.
Contemporary heart rate models typically exist within a five-zone framework. The first zone is relegated to recovery, the second is relegated to “aerobic base,” the third is relegated to pace or tempo training, the fourth is relegated to “threshold” training, and the fifth is considered “VO2 Max.” While all of this is mostly acceptable for general use, the typical five-zone framework is often wildly inaccurate from a physiological perspective.[18]
For example, all too often does an individual perform “aerobic” work at the heart rate assigned to “Zone 2,” but, in reality, they’ve already surpassed the physiological marker indicative of greater proportional anaerobic metabolism (this is the first lactate threshold, called the anaerobic threshold in older literature.) Zone 2 cardio, as it is often intended, aims to remain below this first threshold, where fat oxidation supplies the bulk of the energy and blood lactate concentrations are generally stable. In reality, many individuals end up overshooting this physiologically, in terms of anaerobic energy contribution and lactate buildup, while their heart rate still reads as within “Zone 2.” For this reason, many clinical settings and elite endurance athletes use a three zone model, based upon the distinct physiological markers of the lactate thresholds, to guide training — but, I digress. This degree of scientific granularity isn’t necessary for most people. What is necessary for most people, however, is some degree of awareness about what makes aerobic (base) training truly aerobic. It must predominantly rely upon the oxidation of fats for energy; this, all else equal, requires low intensities and long durations.
The practical solution to determine if aerobic training is actually aerobic, beyond the niches of exercise physiology or alpinism, is to consider the following: is it actually easy? If patients are describing aerobic workouts as intense, they’re likely not truly aerobic in nature. Even “moderate” is often pushing it, in terms of intensity for true aerobic training. The bulk of aerobic work should be easy and sustained for long durations (at least twenty minutes, up to about two hours.) This looks like walking, rucking with a reasonable load, stationary biking, and perhaps some jogging or swimming (if the patient is very economical at those activities.) When in doubt, slow down. A few higher intensity sessions per week may be appropriate for developing the upper-end of aerobic fitness and maximal oxygen consumption (VO2), but this is a quality independent of the aerobic base, which resides below the first lactate threshold. Sprints are never a replacement for long, sustained, easy, often-boring aerobic work. The benefits of long, easy, truly aerobic exercise are manifold and not just chemical in nature. Yes, the patient will likely display improvements in chemical measures of metabolic health as a result of chronic aerobic training — but, increased mitochondrial density in tissues, lower visceral fat mass, lower average blood pressures, reduced risk of cardiac events, structural cardiac adaptations (increased stroke volume), and numerous other adaptations are likely to occur, as well.[19,20,21,22,23] Genuine aerobic training, with a specific intended outcome, is a reliable and effective tool for preventative care.[24]
Figure 17-2. Lactic Acid Thresholds
*Perceived intensity is not always an accurate gauge of exercise metabolism: an aerobically deficient athlete can feel an effort is “easy” while blood lactate sits above 4 mmol/L (beyond LT2), because a highly developed anaerobic system is supplying the energy, running on carbohydrate from the start.
- : In terms of physiological markers, the majority of aerobic training should occur below the first lactate threshold, typically measured at about ~2 mmol/L, although this varies across patients.[25]
- : A simple method for the patient to determine appropriate intensity of aerobic exercise is the “talk test.” They should be able to speak in full sentences, without strain, for the duration of low-intensity aerobic training. When in doubt, slow down — it should feel easy.
- : For patients in need of a truly accurate assessment of lactate thresholds, a field or laboratory lactate threshold test (measuring blood lactate concentrations) is the only clinically-reliable method. Many universities or human performance programs offer this service. This degree of precision is certainly far from mandatory, barring elite populations, but it is certainly a useful measurement for prescription of aerobic training.
Neural: Development and Practice of Task-Relevant Skills
Neural adaptation is an interesting aspect of physical training, one that still continues to be a point of contention across the world of human performance, exercise physiology, and health science. As such, I’ll keep this section brief and practical: neural adaptations, in the context of physical training, often manifest as increased efficiency, precision, and consistency in performance of task-specific skills. For a competitive weightlifter, this may look like higher firing rates of motor units, generating massive forces in short times, as a consequence of repeatedly and progressively training the same, explosive motor patterns. A tactical athlete may display greater economy of movement when operating under conditions of prolonged or significant fatigue, due to previous practice of task-specific motor patterns — like negotiating obstacles. For an aging patient, neural adaptations may appear as more consistent balance when walking across an unstable surface or greater ease standing up from a chair. The body adapts to what it repeatedly does, or fails to do. In the most practical terms, neural adaptations, as a consequence of physical training, are often a simple consequence of practice. In the context of preventative care, it’s important to consider potential risks and hazards that the patient may likely face. If the patient is at statistical risk of falling, perhaps it’s worth intentionally developing balance and task-specific coordination prior to walking down an icy driveway.[26,27]
Training as Prescription: From Clinic to Deployment
Much like the prescription of a medicine, effective physical training should be appropriate for the condition, precise in delivery, and dosed accordingly to achieve the intended effect. When utilized in this manner, physical training, not just physical activity, can be one of the most potent tools available for preventative care; the entire human body can be progressively developed, fortified, and refined according to individual circumstances.[20,22,24]
Furthermore, integration of effective physical training and human performance programs with existing healthcare frameworks allows for an uncommon degree of robustness and proactivity in preventative care. Consideration of this sort of model is of special importance for military pre-, mid, and post-deployment optimization, as well as any for individuals in austere environments where access to effective care may be inconsistent or delayed.[28,29,30,31,32,33]
Frequently Asked Questions
Is physical training still useful for an untrained patient with existing medical conditions?
I recognize the benefits of structured training, but I don’t have the practical experience to implement it. What is the best approach?
How do I identify priorities for physical training, in the context of preventative care?
What wearable devices do you recommend for tracking heart rate or HRV?
What is the ideal method for strength training and metabolic conditioning?
How do I calculate my zone 2 heart rate?
What is the difference between the lactate threshold and the anaerobic threshold?
How long does it take to recover from overtraining?
How do I test my VO2 max?
Have additional questions regarding the role of physical training in preventative care? Please feel free to email me at brandon@grailstrength.com — I hope to be of service, however I can be. Find Grail Strength at grailstrength.com.
References
- Selye H. Stress and the general adaptation syndrome. Br Med J. 1950;1(4667):1383-1392.
- Henry FM. Specificity vs. generality in learning motor skill. In: Brown RC, Kenyon GS, eds. Classical Studies on Physical Activity. Prentice-Hall; 1968.
- Wattanapisit A, Lapmanee S, Chaovalit S, Lektip C, Chotsiri P. Prevalence of physical activity counseling in primary care: a systematic review and meta-analysis. Health Promot Perspect. 2023;13(4):254-266. doi:10.34172/hpp.2023.31
- MacDonald C, Bennekou M, Midtgaard J, Langberg H, Lieberman DE. Clarifying the real challenge: adherence, not efficacy, is the barrier to exercise as medicine. Br J Sports Med. 2025;59(24). doi:10.1136/bjsports-2025-110988
- Nuzzo JL, Pinto MD, Kirk BJC, Nosaka K. Resistance exercise minimal dose strategies for increasing muscle strength in the general population: an overview. Sports Med. 2024;54(5):1139-1162. doi:10.1007/s40279-024-02009-0
- Paluch AE, Boyer WR, Franklin BA, et al. Resistance exercise training in individuals with and without cardiovascular disease: 2023 update: a scientific statement from the American Heart Association. Circulation. 2024;149(3):e217-e231. doi:10.1161/CIR.0000000000001189
- Currier BS, D'Souza AC, Singh MAF, et al. American College of Sports Medicine position stand: resistance training prescription for muscle function, hypertrophy, and physical performance in healthy adults: an overview of reviews. Med Sci Sports Exerc. 2026;58(4):851-872. doi:10.1249/MSS.0000000000003897
- D'Onofrio G, Kirschner J, Prather H, Goldman D, Rozanski A. Musculoskeletal exercise: its role in promoting health and longevity. Prog Cardiovasc Dis. 2023;77:25-36. doi:10.1016/j.pcad.2023.02.006
- Shen Y, Shi Q, Nong K, et al. Exercise for sarcopenia in older people: a systematic review and network meta-analysis. J Cachexia Sarcopenia Muscle. 2023;14(3):1199-1211. doi:10.1002/jcsm.13225
- Tøien T, Berg OK, Modena R, Brobakken MF, Wang E. Heavy strength training in older adults: implications for health, disease and physical performance. J Cachexia Sarcopenia Muscle. 2025;16(2):e13804. doi:10.1002/jcsm.13804
- López-Bueno R, Ahmadi M, Stamatakis E, Yang L, Del Pozo Cruz B. Prospective associations of different combinations of aerobic and muscle-strengthening activity with all-cause, cardiovascular, and cancer mortality. JAMA Intern Med. 2023;183(9):982-990. doi:10.1001/jamainternmed.2023.3093
- Zhang Y, Lee DH, Rezende LFM, Ma Y, Giovannucci E. Long-term resistance training with all-cause and cause-specific mortality: assessing dose-response and joint associations with aerobic physical activity. Br J Sports Med. 2026;60(12):874-883. doi:10.1136/bjsports-2025-110503
- Zhang T, Zhang Y, Lee DH, et al. Long-term resistance training and risk of type 2 diabetes. JAMA Netw Open. 2026;9(6):e2619420. doi:10.1001/jamanetworkopen.2026.19420
- Terada T, Pap R, Thomas A, et al. Effects of muscle strength training combined with aerobic training versus aerobic training alone on cardiovascular disease risk indicators in patients with coronary artery disease: a systematic review and meta-analysis of randomised clinical trials. Br J Sports Med. 2024;58(20):1225-1234. doi:10.1136/bjsports-2024-108530
- O'Shea P. Quantum Strength & Power Training: Gaining the Winning Edge. 1996.
- Swift DL, Ross LM, Laddu DR, et al. Role of physical activity in obesity treatment and cardiometabolic health: a scientific statement from the American Heart Association. Circulation. 2026;154(1):e1-e16. doi:10.1161/CIR.0000000000001441
- US Department of Health and Human Services. Physical Activity Guidelines for Americans. 2nd ed. US Dept of Health and Human Services; 2018.
- Bishop DJ, Beck B, Biddle SJH, et al. Physical activity and exercise intensity terminology: a joint American College of Sports Medicine (ACSM) expert statement and Exercise and Sport Science Australia (ESSA) consensus statement. Med Sci Sports Exerc. 2025;57(11):2599-2613. doi:10.1249/MSS.0000000000003795
- Garcia L, Pearce M, Abbas A, et al. Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies. Br J Sports Med. 2023;57(15):979-989. doi:10.1136/bjsports-2022-105669
- Lang JJ, Prince SA, Merucci K, et al. Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations from 199 unique cohort studies. Br J Sports Med. 2024;58(10):556-566. doi:10.1136/bjsports-2023-107849
- Mi MY, Perry AS, Krishnan V, Nayor M. Epidemiology and cardiovascular benefits of physical activity and exercise. Circ Res. 2025;137(2):120-138. doi:10.1161/CIRCRESAHA.125.325526
- Sanchis-Gomar F, Lavie CJ, Rodriguez F, Kokkinos P, Franklin BA. Physical activity, fitness, and longevity. Prog Cardiovasc Dis. Published online July 22, 2026. doi:10.1016/j.pcad.2026.07.004
- Edwards JJ, Deenmamode AHP, Griffiths M, et al. Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials. Br J Sports Med. 2023;57(20):1317-1326. doi:10.1136/bjsports-2022-106503
- Rahmati M, Lee H, Lee H, et al. Associations between exercise training, physical activity, sedentary behaviour and mortality: an umbrella review of meta-analyses. J Cachexia Sarcopenia Muscle. 2025;16(2):e13772. doi:10.1002/jcsm.13772
- House S, Johnston S, Jornet K. Training for the Uphill Athlete: A Manual for Mountain Runners and Ski Mountaineers. Patagonia; 2019.
- US Preventive Services Task Force, Nicholson WK, Silverstein M, et al. Interventions to prevent falls in community-dwelling older adults: US Preventive Services Task Force recommendation statement. JAMA. 2024;332(1):51-57. doi:10.1001/jama.2024.8481
- Guirguis-Blake JM, Perdue LA, Coppola EL, Bean SI. Interventions to prevent falls in older adults: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2024;332(1):58-69. doi:10.1001/jama.2024.4166
- Bunn PDS, Sodré RDS, Matos MI, et al. Effects of prevention programmes on injury risk in military personnel: a systematic review with meta-analysis. BMJ Mil Health. 2024;170(6):529-536. doi:10.1136/bmjmilitary-2022-002098
- Lovalekar M, Keenan KA, Peterson P, et al. Neuromuscular strength and power predict musculoskeletal injury and attrition during Marine Corps recruit training. Mil Med. 2024;189(suppl 2):12-20. doi:10.1093/milmed/usae134
- Robitaille E, Reilly T, Heipel S, Buttici H, Chasse E, Tingelstad HC. The value of strength as a predictor of musculoskeletal injury in Canadian Armed Forces basic infantry candidates. Mil Med. 2024;189(7-8):e1675-e1682. doi:10.1093/milmed/usae015
- Foulis SA, Proctor SP, Spiering BA, et al. Model for musculoskeletal injury risk factors among US Army basic combat trainees. JAMA Netw Open. 2025;8(6):e2513177. doi:10.1001/jamanetworkopen.2025.13177
- Pietiläinen E, Parkkola K, Vasankari T, Santtila M, Luukkaala T, Kyröläinen H. Physical activity, physical fitness and cardiometabolic health among Finnish military workers. BMJ Mil Health. 2025;171(e1):e44-e50. doi:10.1136/military-2024-002800
- Acevedo AM, Zeigler Z. Human performance optimization in Special Operations Forces: structure, outcomes, and readiness implications. Mil Med. Published online July 2, 2026. doi:10.1093/milmed/usag303
- Meeusen R, Duclos M, Foster C, et al. Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Med Sci Sports Exerc. 2013;45(1):186-205. doi:10.1249/MSS.0b013e318279a10a
Educational content only. This guest dispatch was written by Brandon Sherwood, CSCS, SSC, USAW-L2 of Grail Strength and medically reviewed by Matthew J. Bertini, MD. Exercise prescription for individuals with medical conditions belongs with their own clinicians; the peer-reviewed literature cited above is provided for context. All clinical services referenced are performed exclusively by licensed physicians through AMC Medicine LTD.
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